English to Russian Science Biology (-tech,-chem,micro-)

murine IgG1 antibody MC-1 was initially humanized by engineering the three MC-1 murine HC CDRs into multiple human HC framework germline genes and the three MC-1 murine LC CDRs into multiple human LC framework germline genes. Humanized constructs of MC-1 utilized 96 different combinations of heavy- and light-chain frameworks, representing each of the twelve HC framework germline families (specific human HC frameworks: 1-24, 1-46, 1-69, 2-05, 3-15, 3-23, 3-53, 3-72, 4-04, 4-39, 5-51, and 6-01) and each of the eight LC germline families (specific human LC frameworks: A-26, A-27, B-2, B-3, L-2, L-12, O11, and O-2).

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