Glossary entry

English term or phrase:

aromatic A-ring derivatives of

Spanish translation:

derivados de [...] con el anillo A aromático

Added to glossary by Yvonne Becker
Jan 28, 2012 02:53
12 yrs ago
6 viewers *
English term

aromatic A-ring derivatives of

English to Spanish Science Chemistry; Chem Sci/Eng
En un artículo titulado "In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone" (Actividad antiprogestacional / antiglucocorticoide in vitro y unión al receptor de progesterona y glucocorticoides de los metabolitos putativos y derivados sintéticos del CDB-2914, CDB-4124 y la mifepristona):

"We have examined the functional activities and potencies, in various cell-based assays, and relative binding affinities (RBAs) for progesterone receptors (PR) and glucocorticoid receptors (GR) of the putative mono- and didemethylated metabolites of CDB-2914, CDB-4124, and mifepristone and of the 17α-hydroxy and **aromatic A-ring derivatives of** CDB-2914 and CDB-4124. The binding affinities of the monodemethylated metabolites for rabbit uterine PR and human PR-A and PR-B were similar to those of the parent compounds. "

Aromatic ring = anillo aromático y derivatives = derivados, pero desconozco a qué se refiere la "A" en este caso.

Muchas gracias por sus sugerencias

Proposed translations

20 mins
Selected

derivados de [...] con el anillo A aromático

Se deduce del contexto que los compuestos CDB-2914 y CDB-4124 tienen un núcleo ciclopentanoperhidrofenantrénico en el que el anillo A no es aromático. Los derivados en cuestián deben obtenerse por acción de la aromatasa.

Saludos cordiales.

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Note added at 28 minutos (2012-01-28 03:21:44 GMT)
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Acá podés ver cómo es el esqueleto de los esteroides y cómo se designan los cuatro anillos (A, B, C y D):

http://www.people.vcu.edu/~urdesai/intro.htm
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4 KudoZ points awarded for this answer. Comment: "Muchas gracias"
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