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Translation, Editing/proofreading
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Specializes in:
Medical: Pharmaceuticals
Medical (general)
Medical: Oncology
Medical: Health Care
Safety
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Open to considering volunteer work for registered non-profit organizations
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Sample translations submitted: 2
English to Chinese: Pharmaceuticals General field: Medical Detailed field: Medical: Pharmaceuticals
Source text - English Preparation of solutions:
Preparation of Reference solution:
Accurately weigh about 6.1 mg of EP Impurity E, 5.0 mg of EP Impurity F and 5 mg of EP Impurity G standard into a 10mL volumetric flask, add 5 mL of Solvent Mixture, sonicate to dissolve and dilute to volume with Solvent Mixture.(Reference Stock-I). Dilute 3 mL of above solution to 25 mL with the Solvent Mixture (Reference Stock II). Dilute 5 mL of above solution to 50 mL with the Solvent Mixture (Reference Stock-III).
Further dilute 3 mL of Above solution into a 20 mL with the Solvent Mixture.
Preparation of sample solution (30 mg/mL):
Weigh about 300 mg of Mirabegron sample into a 10mL volumetric flask, add 5 mL of Solvent Mixture, sonicate to dissolve and dilute to volume with Solvent Mixture. (Final resulting concentration of sample solution is 30 mg/mL)
Note: Store the solution protected from light.
Procedure:
Separately inject 15 µL of solutions as mentioned in the sequence table.
Relative retention with reference to mirabegron (retention time = about 13 min): impurity E = about 0.7;
impurity F = about 1.6; impurity G = about 1.7.
System suitability criteria:
The system is said to be suitable if,
1. The signal to noise ratio for Impurity E, F, G from Reference solution injection should be more than 10.
2. The % RSD for the area response of Impurity E, F, G in Reference solution from six replicate injections should be not more than 10.0%.
EXPERIMENTAL PLAN AND DATA EVALUATION:
The method verification shall be executed as per the following plan.
The experiment may be done as sequential or parallel operations.
The Quality Assurance authorized personnel shall authorize any deviations during the activity.
Specificity
Precision
System precision
Method precision
Intermediate precision
Limit of Quantification and Limit of Detection
Linearity
Range
Accuracy
Solution stability
Mobile phase stability
Standard solution stability
Sample solution stability
Batch analysis:
Translation - Chinese 溶液制备：
对照品溶液的制备：
精密称取约 6.1 mg EP 杂质 E、5.0 mg EP 杂质 F 和 5 mg EP 杂质 G 对照品品，置于 10 mL 容量瓶中，加入 5 mL 溶剂混合物，超声溶解，并用溶剂混合物稀释至刻度。（对照品储备液 I）。量取上述溶液 3 mL，用溶剂混合物稀释至 25 mL（对照品储备液 II）。量取上述溶液 5 mL，用溶剂混合液稀释至 50 mL（对照品储备液 III）。
取上述溶液 3 mL，用溶剂混合液进一步稀释至 20 mL。
样品溶液 (30 mg/mL) 的制备：
称取约 300 mg 米拉贝隆样品，置于 10 mL 容量瓶中，加入 5 mL 溶剂混合物，超声溶解，然后用溶剂混合物稀释至刻度。（样品溶液的最终浓度为 30 mg/mL）
注：溶液避光储存。
程序：
按序列表分别进样 15 µL 溶液。
各杂质与米拉贝隆（保留时间 = 约 13 min）的相对保留时间：杂质 E = 约 0.7；
杂质 F = 约 1.6；杂质 G = 约 1.7。
系统适用性标准：
如果符合以下条件，则认为该系统适用：
1. 对照品溶液进样中杂质 E、F、G 的信噪比应大于 10。
2. 6 次重复进样所得对照品溶液中杂质 E、F、G 峰面积响应值的 RSD % 不得过 10.0%。
English to Chinese: non-clinical General field: Medical Detailed field: Medical (general)
Source text - English Surgical procedure for ischemic-reperfusion SCI Model ASCI was induced by the aortic cross-clamping method as described previously.21,22 Three rabbits were used in each dosing group. Each animal was anesthetized with an intramuscular injection of xylazine (10 mg/kg) and ketamine (100 mg/kg). An ear vein catheter (22 gauge) was placed for the administration of additional medications and intravenous fluids. Heparin 150 IU/kg was given intravenously and allowed to circulate for 5 min and a 0.9% NaCl solution was infused at a rate of 25 ml/h during the procedure. The abdomen was prepared under sterile conditions and draped. A midline laparotomy was made and the viscera was reflected to the right. The abdominal aorta was then clamped with vascular clamps. One clamp was positioned just below the left renal artery and another was placed at the aortoiliac bifurcation. Each animal underwent 40 min of spinal cord ischemia. The technique of collectively clamping the great vessels produces spinal cord ischemia in the rabbit and after 40 min all control animals were rendered paraplesic,23,24 and its reliability and reproducibility is well known.25 Surgical procedure for the transection SCI model Each three-rabbit per group underwent the same anesthetic management, and an ear vein catheter (22 gauge) was placed to administer additional medications and intravenous fluids. Briefly, the lumbodorsal fascia region was exposed and cut in the midline of the spinous processes after a dorsal skin incision of the L2–L4 region. The paraspinous muscle was then separated from the spinous process and the lamina. Bone extending out laterally from the spinous process was removed with a ronguer (laminectomy). It was easier to remove the lamina if the bone was first thinned with a high-speedrotating burr. Once the spinal cord was exposed, spinal cord transection was performed using fine cut scissors or blade between the L2–L3 and L3–L4 region. Ceftazimine was injected intramuscularly with a single dose at 30 mg/kg.
Lu Ren: English-Chinese Translator and Proofreader
Experienced and meticulous translator with over 6 years of experience bridging the communication gap between English and Chinese (Simplified Chinese native). I am passionate about delivering accurate and culturally-appropriate translations across various industries, ensuring clear and concise communication for your target audience.
My Expertise:
Life Sciences & Medical: Clinical trials, reports, protocols, drug information, etc.
Medical Materials: IFUs, user manuals, and technical documents.
Legal: Contracts, terms & conditions, and other legal documents.
Document Translation: All types of certificates, transcripts, and personal documents.
Key Skills:
Accuracy & Quality: 100% quality guarantee with meticulous attention to detail.
Efficiency & Timeliness: Reliable delivery on time, every time.
Cultural Nuance: Deep understanding of both English and Chinese cultures for natural-sounding translations.
Software Proficiency: Adept in Trados Studio 2021, Memoq 9.9, and Microsoft Office Suite.
Confidentiality: Committed to safeguarding your sensitive information.
Member since Apr '24
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