English to Italian Medical Genetics Antibodies

a "humanized" antibody or antigen binding protein, may be engineered
(for example "germlined") to decrease its immunogenicity, increase its affinity, alter its specificity, or for other purposes.

The VH and VL domains of the invention, in
certain embodiments, are germlined, i.e., the framework regions (FRs) of these domains are changed using conventional
molecular biology techniques to match the consensus amino acid sequences of human germline gene products