half-maximum blocking concentrations

Homework / test English to Italian Medical Medical: Pharmaceuticals Clinical research

Hexylresorcinol, amylmetacresol and dichloro-benzylalcohol reversibly blocked depolarisation-induced whole-cell sodium inward currents.
The half-maximum blocking concentrations (EC50)at -150 mV were 23.1, 53.6 and 661.6 цМ, respectively.
Block induced by hexylresorcinol and amylme-tacresol was increased at depolarised potentials and *use-dependent during trains of depolarisations* applied at high frequency (100 Hz) indicating that both drugs bind more tightly to inactivated conformations of the channel.